THEORY OF FAST WALKING WITH HUMAN-DRIVEN LOAD-CARRYING ROBOT EXOSKELETONS


The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

Summary: CHK1 inhibitors exhibit dose-limiting toxicity despite potent tumor cytotoxicity in clinical trials.Here, we reveal that low-dose prexasertib induces mtDNA Lens Accessories damage by impairing repair machinery, triggering cytosolic mtDNA release via VDAC1 to activate STING-mediated innate immunity.Mechanistically, prexasertib blocks CHK1 p

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A machine learning approach for rapid early detection of Campylobacter spp. using absorbance spectra collected from enrichment cultures.

Enumeration of Campylobacter from environmental waters can be difficult due to its low concentrations, which can still pose a significant health risk.Spectrophotometry is an approach commonly used for fast detection of water-borne pollutants in water samples, but it has not been used for pathogen detection, which is commonly done through a laboriou

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Intramuscular depot formulations of leuprolide acetate suppress testosterone levels below a 20 ng/dL threshold: a retrospective analysis of two Phase III studies

Aaron Spitz,1 Marc Gittelman,2 Lawrence I Karsh,3 Sanja Dragnic,4 Ahmed M Soliman,5 Aditya Lele,6 Damian Gruca,7 Michael Norton4 1Orange County Urology Associates, Laguna Beach, CA, 221st Century Oncology/UroMedix-Aventura Division, Aventura, FL, 3The Urology Center of Colorado, Denver, CO, 4US Medical Affairs, 5Health Economics and Outcomes Resear

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